Adrenaline (Epinephrine) Autoinjectors Frequently Asked Questions

The following frequently asked questions (FAQ) and answers about adrenaline autoinjectors are based on inquiries that have been received by, or forwarded to ASCIA since 2003. This document is regularly updated as new information becomes available.

pdfASCIA PCC Adrenaline autoinjector FAQ 2019173.49 KB

Q 1: What are adrenaline autoinjectors?

Adrenaline autoinjectors are automatic injectors that contain a single, fixed dose of adrenaline, designed for use by anyone, including people who are not medically trained.

Q 2: Why do you need to use adrenaline to treat anaphylaxis?

Adrenaline is the first line emergency treatment for anaphylaxis. Anaphylaxis is a potentially life threatening allergic reaction and must be treated promptly. Adrenaline works rapidly (within minutes) to reduce throat swelling, open up the airways and maintain blood pressure. Withholding or delaying adrenaline may result in deterioration and potentially death of an individual experiencing anaphylaxis.

Q 3: What types of adrenaline autoinjectors are available?

In Australia and New Zealand, there are currently two doses of adrenaline autoinjectors available:

  • EpiPen® (0.3mg) is usually prescribed for adults and children over 20kg
  • EpiPen®Jr (0.15mg) is usually prescribed for children 7.5*-20kg  

To access training videos, updated ASCIA Action Plans for Anaphylaxis and other resources go to  

* Whilst 10-20kg was the previous weight guide for a 0.15mg adrenaline autoinjector device, a 0.15mg device may now also be prescribed for an infant weighting 7.5-10kg by health professionals who have made a considered assessment. Use of a 0.15mg device for treatment of infants weighing 7.5kg or more poses less risk, particularly when used without medical training, than use of an adrenaline ampoule and syringe.

Q 4: Who can use an adrenaline autoinjector?

Adrenaline autoinjectors have been designed for use by anyone in an emergency, including people who are not medically trained, such as a friend, teacher, early childhood education/care centre worker, parent, passer-by, bystander or the individual with anaphylaxis themselves (if they are well and old enough). Instructions are shown on the label of each device and on the ASCIA Action Plan for Anaphylaxis.

Q 5: If I'm not sure it is anaphylaxis should I use an adrenaline autoinjector?

If in doubt, it is better to use an adrenaline autoinjector, than not use it, even if in hindsight the reaction is not anaphylaxis. Under-treatment of anaphylaxis is more harmful (and potentially life threatening), than over-treatment of a mild to moderate allergic reaction. If in doubt, give the adrenaline autoinjector.

Q 6: If I am not sure if a person is experiencing asthma or anaphylaxis, when should an adrenaline autoinjector be used?

In a person with asthma, who also has allergies and is at risk of anaphylaxis, the adrenaline autoinjector should be used first, followed by asthma reliever medication, calling an ambulance, continuing asthma first aid and following the ASCIA Action Plan for Anaphylaxis.

If someone with known food or insect allergy suddenly develops severe asthma-like symptoms, give adrenaline autoinjector FIRST, then asthma reliever medication.

Q 7: Why do adrenaline autoinjectors need to be administered into the outer mid thigh?

Adrenaline is most rapidly absorbed when the autoinjector is administered into the muscle of the outer mid thigh (compared to other parts of the body), as shown in the diagrams on the label of the device, the package insert, and the ASCIA Action Plan for Anaphylaxis.

Injecting adrenaline into the muscle of the outer mid thigh makes it extremely unlikely that damage to nerves and tendons will occur, or that it will be accidentally be injected into an artery or vein. It is also the least painful part of the body to give an injection. Adrenaline autoinjectors can be administered through a single layer of clothing, but not through seams, or pockets.

Q 8: What needs to be done after using an adrenaline autoinjector?

An ambulance should be called immediately after using an adrenaline autoinjector to take the individual to hospital, so they can be given further treatment and remain under observation for at least four hours. The used adrenaline autoinjector should be provided to the ambulance or medical staff as well as the time it was given. Transient (temporary) side effects of adrenaline (e.g. increased heart rate, trembling and pallor), are to be expected.

Q 9: Before, during and after using the adrenaline autoinjector should the person with anaphylaxis be sitting, standing or lying down?

It is important to lay a person with anaphylaxis flat to improve blood flow to the heart. An upright standing position  can lead to insufficient blood returning to the heart, a subsequent drop in blood pressure and increased risk of death. If breathing is difficult, allow the person to sit, but not stand. If vomiting or unconscious, lay the person on their side in the recovery position.

The individual experiencing anaphylaxis should not walk to their medication, therefore the adrenaline autoinjector should be brought to them as quickly as possible.

Q 10: What should a person avoid doing when they have anaphylaxis?

Under no circumstances should a person with anaphylaxis take a shower, even if they feel very hot, for the following reasons:

  • Standing can cause a further drop in blood pressure.
  • Warm showers promote vasodilation (widening of the blood vessels) which can also lower blood pressure.
  • Bathroom floors are hard, so there is a greater risk of injury if the person faints and falls.

They should also not eat or drink anything, as this can cause them to vomit, which may be inhaled (aspirated).

Q 11: When does an additional adrenaline autoinjector need to be used?

Further adrenaline doses may be given if there is no response five minutes after giving the previous dose.

Q 12: Why are two adrenaline autoinjectors usually prescribed for a person at risk of anaphylaxis?

For children in early childhood education/care centres or school, having two adrenaline autoinjectors allows you to keep one with your child at all times (whilst in or out of the home), and another at the early childhood education/care centre or school.

For older children or adults, this allows them to keep two adrenaline autoinjectors with them at all times, in case more than one dose of adrenaline is required.

Two adrenaline autoinjectors are PBS subsidised in Australia for a person at risk of anaphylaxis and additional devices can be purchased at full price from pharmacies. Currently there is no Pharmac subsidy for adrenaline autoinjectors in New Zealand.

Q 13: Can adrenaline autoinjectors be re-used?

No. Each adrenaline autoinjector only releases a single, fixed dose of adrenaline once the device is triggered.

Q 14: What precautions should be taken when using an adrenaline autoinjector?

There are no absolute contraindications (factors which make it unwise to give treatment) for use of an adrenaline autoinjector in a person who is experiencing anaphylaxis. However, it is important to follow the instructions and ensure that the needle end of the adrenaline autoinjector is on the individual's outer mid thigh and that the needle is not touched after administration, to avoid needle stick injury.

Q 15: Where should adrenaline autoinjectors be stored?

Adrenaline autoinjectors should be kept out of the reach of small children, however, they must be readily available when needed and not in a locked cupboard. An ASCIA Action Plan for Anaphylaxis should always be stored with an adrenaline autoinjector as the plan provides instructions on how to use the adrenaline autoinjector and indicates signs and symptoms of anaphylaxis. ASCIA Action Plans are available on the ASCIA website: 

Q 16: At what temperature should adrenaline autoinjectors be stored?

Adrenaline is light and heat sensitive so adrenaline autoinjectors need to be stored in a cool, dark place at room temperature, between 15°C and 25°C. If the temperature fluctuates below 15°C or above 25°C autoinjectors should be stored in an insulated wallet. These are available from patient organisations. Adrenaline autoinjectors must not be refrigerated nor stored on ice as temperatures below 15°C may damage the autoinjector mechanism.

Q17: At what age can students carry their own adrenaline autoinjector whilst at school?

A prescription for two adrenaline autoinjectors allows one to remain with your child at all times (whilst in or out of the home) and another to be kept at school or the early childhood education/care centre.

High school and upper primary school students should usually carry at least one device on their person.

The decision as to whether a student can carry their own adrenaline autoinjector should be made when developing the student’s anaphylaxis management plan, in consultation with the student, their parents/guardians and their medical practitioner. This decision is generally based on a combination of factors, including age, maturity and ability to use the device.

If a student carries their own adrenaline autoinjector device they:

  • May not physically be able to self-administer due to the effects of anaphylaxis.
  • Should be educated that if they self-administer, they should immediately alert a staff member and an ambulance must be called.
  • Need to have a second adrenaline autoinjector (provided by the parent/guardian) kept on site at the school in an easily accessible, unlocked location that is known to all staff.
Q 18: When do adrenaline autoinjectors expire?

The shelf life of adrenaline autoinjectors is normally around one to two years from date of manufacture. The expiry date on the side of the device needs to be marked on a calendar and the device must be replaced prior to this date. Registration with a reminder service (e.g. may be of assistance as they provide reminders about expiry dates.

Adrenaline autoinjectors with discoloured adrenaline or expired adrenaline autoinjectors are not as effective when used for treating anaphylaxis and should therefore not be relied upon to treat anaphylaxis. However, the most recently expired adrenaline autoinjector available should be used if no in-date device is available.

Q 19: Who should be prescribed the Junior (0.15mg) version of adrenaline autoinjectors?

ASCIA Prescribing Guidelines recommends a 0.15mg adrenaline autoinjector (e.g. EpiPen®Jr) for children weighing 7.5-20kg and a 0.3mg adrenaline autoinjector (e.g. EpiPen®) for adults and children weighing more than 20kg.

This recommendation is based on consensus and standard practice by ASCIA members.

Q 20: Can a higher dose of adrenaline be given to a young child if no lower dose (0.15mg) device is available?

A general guide to adrenaline autoinjector dose is as follows:

  • Children under 7.5kg are not usually prescribed an adrenaline autoinjector. If anaphylaxis is suspected only a  0.15mg device should be given. Higher dose adrenaline autoinjectors should NOT be administered to children under 7.5kg.
  • In children weighing 7.5-20kg, a 0.15mg adrenaline autoinjector should be used. However, if only a 0.3mg device is available, this should be used in preference to not using one at all.
  • In children over 20kg or adults, a 0.3mg adrenaline autoinjector should be used. However if only a 0.15mg device is  available, this should be used in preference to not using one at all.
Q 21: Are adrenaline autoinjectors available at a subsidised rate?

In Australia, adrenaline autoinjectors are available on the Pharmaceutical Benefits Scheme (PBS) for patients diagnosed to be at high risk of anaphylaxis. The PBS listing as at 1 July 2010 is as follows: Authority approvals are limited to a maximum quantity of two adrenaline autoinjectors (EpiPens) at any one time. Repeat approvals for PBS subsidised devices will not be issued unless the device is about to expire or is used.

In New Zealand adrenaline autoinjectors are not currently subsidised by Pharmac.

Q 22: What documents do I require to take an adrenaline autoinjector in my airline flight hand luggage?

ASCIA has developed a Travel Plan for people at risk of anaphylaxis which needs to be completed and signed by the individual's treating doctor and attached to the ASCIA Action Plan for Anaphylaxis.

The patient support organisation Allergy & Anaphylaxis Australia, also has information on travelling with severe food allergies: 

It is prudent for individuals to carry their adrenaline autoinjector in a container which includes a pharmacy label (particularly if travelling in the USA). Individuals should notify their travel agent, insurer and airline of their allergy and the need to carry an adrenaline autoinjector, in case additional documentation or preparation is required.

Further information about travelling with allergies including a checklist, is available from the ASCIA website: 

Q 23: Are adrenaline autoinjectors available without a prescription?

Yes. Adrenaline autoinjectors are available from pharmacies without a prescription at full retail price (not PBS subsidised). If they are purchased directly from pharmacies without a prescription, training from the pharmacist on how to use the adrenaline autoinjector should be requested.

Q 24: Can an adrenaline autoinjector be purchased for general use (e.g. for inclusion in a first aid kit)?

Some schools, early childhood education/care centres, workplaces and restaurants choose to purchase an adrenaline autoinjector for general use, which serves as a back-up for the adrenaline autoinjectors prescribed for an individual person. These should not be used as a substitute for a person at risk of anaphylaxis having their own prescribed adrenaline autoinjector/s.

In most regions an adrenaline autoinjector for general use may be administered to a person who appears to have anaphylaxis, but have not been previously diagnosed to be at risk of anaphylaxis. Advice and training from the local education and/or health authorities should be sought regarding adrenaline autoinjectors for general use. Further information about adrenaline autoinjectors for general use is available on the ASCIA website: 

Q 25: Why are adrenaline autoinjectors used to treat anaphylaxis in non-medical settings, instead of adrenaline ampoules, needles and syringes?

ASCIA recommends that adrenaline autoinjectors are used to treat anaphylaxis in schools, early childhood education/care centres, and any other non-medical setting, to avoid delay in adrenaline administration and ensure that the correct dose of adrenaline is given.

Whilst adrenaline ampoules, needles and syringes are suitable for use by trained health professionals in medical settings to treat anaphylaxis, they are unsuitable for use in non-medical settings such as schools, early childhood education/care centres, and workplaces, as it is not feasible for school and early childhood educators to be trained in the use of ampoules, needles and syringes. This is a health professional (medical/nursing) skill that is beyond the parameters of first aid care.

Q 26: Where can I obtain adrenaline autoinjector training devices?

Autoinjector trainer devices (which can be re-used for practice as they do not contain adrenaline and do not have needles) are available from pharmacies, patient support organisations and the adrenaline autoinjector distributors in Australia and New Zealand.
Instructional videos are available on the ASCIA website 

Q 27: Where can I obtain information about training?
ASCIA anaphylaxis e-training is available on the ASCIA website and is free of charge: 

ASCIA is a professional medical society and does not conduct face-to-face anaphylaxis training. The ASCIA website includes links to government and relevant patient organisation websites and most of these include information on how to access face to face training in different regions.

Q 28: Where can I obtain other information?

Anaphylaxis resources section of the ASCIA website: 

Patient support organisations:

Adrenaline autoinjector distributors in Australia and New Zealand:

Q 29: Are adrenaline autoinjectors available at the moment?

For adrenaline autoinjector supply updates go to 

© ASCIA 2021

ASCIA is the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand.

ASCIA resources are based on published literature and expert review, however, they are not intended to replace medical advice. The content of ASCIA resources is not influenced by any commercial organisations.

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Updated March 2021

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