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Autoimmune Diseases

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Autoimmune diseases are a broad range of related diseases in which a person’s immune system produces an inappropriate response against its own cells, tissues and/or organs, resulting in inflammation and damage. There are over 80 different autoimmune diseases, and these range from being common to very rare.  Some autoimmune diseases affect mainly one part of the body (such as multiple sclerosis, autoimmune thyroid disease, type 1 diabetes) whilst others can affect many parts of the body (such as systemic lupus erythematosus, rheumatoid arthritis and systemic vasculitis).   

Autoimmune diseases include common and rare diseases

Autoimmune diseases affect around 5% of people and are one of the most important health issues in Australia and New Zealand.  Common autoimmune diseases such as thyroiditis, rheumatoid arthritis and diabetes affect more than 1% of people. 

In contrast, SLE (Systemic Lupus Erythematosus) affects less than 0.1% of people and is more common and severe in indigenous Australians, Polynesians and those with descendants from Southeast Asia .

What causes autoimmune diseases?

The causes of autoimmune diseases are not yet known.  In many cases it appears that there is some inherited tendency.  However, other factors such as infections and some drugs may play a role in triggering autoimmune diseases.

How are autoimmune diseases diagnosed?

Autoimmune diseases are usually diagnosed using a combination of clinical history, blood tests (autoantibodies, inflammation, organ function) and other investigations such as x-rays.  Sometimes a biopsy of affected tissues may be required for diagnosis.

Localised (organ specific) autoimmune diseases

Whilst localised (organ specific) autoimmune diseases mainly affect a single organ or tissue, the effects frequently extend to other body systems and organs.  These diseases are often managed by organ-specific Medical Specialists, such as endocrinologists, gastroenterologists, neurologists or rheumatologists. 

Systemic autoimmune diseases

Systemic autoimmune diseases can affect many body organs and tissues at the same time. 

They can be broadly classified into rheumatological/connective tissue disease and vasculitis (inflammation of blood vessels).  These diseases are often managed by clinical immunology/allergy specialists and/or rheumatologists..

Examples of localised (organ specific) autoimmune diseases

Addison’s disease (adrenal)

Autoimmune hepatitis (liver)

Coeliac disease (gastrointestinal tract)

Crohn’s disease (gastrointestinal tract)

Diabetes Mellitis Type 1a (pancreas)

Grave’s disease (thyroid)

Guillain-Barre syndrome (nervous system)

Hashimoto’s thyroiditis (thyroid)

Multiple sclerosis (nervous system)

        Myasthenia gravis (nerves, muscles)

Pernicious anaemia (stomach)

Primary biliary cirrhosis (liver)

Sclerosing cholangitis (liver)

Ulcerative colitis (gastrointestinal tract)


Examples of rheumatological systemic autoimmune diseases

Antiphospholipid antibody syndromes (blood cells)

Dermatomyositis (skin, muscles)

Mixed connective tissue disease

Polymyalgia rheumatica (large muscle groups)

Polymyositis (skin, muscles)

Primary Raynaud’s disease (blood vessels)

Rheumatic fever

Rheumatoid arthritis (joints, less commonly lungs, skin, eyes)

Scleroderma (skin, intestine, less commonly lungs, kidneys)

Sjögren’s syndrome (salivary glands, tear glands, joints)

Systemic Lupus Erythematosus (skin, joints, kidneys, heart, brain, red blood cells, other)


Examples of vasculitis disorders


Churg-Strauss syndrome (lungs, skin, nerves)

Cryoglobulinaemia (skin, kidneys, nerves)

Goodpasture’s syndrome (lungs, kidneys)

Henoch-Schonlein purpura (skin, joints, kidneys, gut)

Microscopic polyangitis (skin, kidneys, nerves)

Wegener’s granulomatosis (sinuses, lungs, kidneys, skin)


Behcet’s disease (mucous membranes, skin, eyes)

Central nervous system vasculitis (brain)

Kawasaki syndrome (skin, mucous membranes, lymph nodes, blood vessels)

Polyarteritis nodosa (kidneys, gut, nerves, skin)


Giant cell (temporal) arteritis (arteries of the head and neck)

Takayasu arteritis (arteries of the head and neck)

Treatment options for autoimmune disease

Currently there are no cures for autoimmune diseases, although there is a wide range of treatment options, which depend on the stage and type of autoimmune disease. The main aims of treatments for autoimmune diseases are to relieve symptoms, minimise organ and tissue damage and preserve organ function. 

Treatment options include:

  • Replacement of end organ functions (such as insulin in diabetes and thyroxine in autoimmune thyroid disease)
  • Non-steroidal anti-inflammatory medications (NSAIDS)
  • Corticosteroid anti-inflammatory medications (such as Prednisolone)
  • Immunosuppressive medications
  • Therapeutic monoclonals (such as TNF inhibitors)
  • Immunoglobulin replacement therapy

Other disorders related or associated with autoimmune diseases

Autoinflammatory disorders occur when the immune system’s inflammatory response is not properly controlled, but are not strictly autoimmune in origin.  This unrestrained inflammation increases the risk of amyloidosis, in which excess protein is deposited in the body, and this can result in kidney failure. Characteristically these disorders present in childhood or adolescence with recurrent attacks of fever, sweats, joint and abdominal pain. A number of different autoinflammatory syndromes have now been described, the most common of which is Familial Mediterranean Fever (FMF). FMF is relatively common among people of Mediterranean descent, occurring in about 1 in 1000 people. Less common examples of autoinflammatory syndromes are Tumour Necrosis Factor (TNF) receptor associated periodic fever syndrome (TRAPS), and Hyper-IgD syndrome (HIDS).

Hypereosinophilic syndromes occur when there are sustained high blood levels of a type of white cell called an eosinophil.  These cells can damage the lining of the heart and nerve endings. Causes of hypereosinophilia include vasculitis, other autoimmune diseases, drug allergy, parasitic disease, malignancy (lymphoma) and eosinophilic leukaemia.  Symptoms include recurrent urticaria (hives) or angioedema, sinus disease with nasal polyps, asthma-like symptoms, pneumonia-like symptoms, recurrent stomach pain, neuropathies (nerve damage) and cardiomyopathy (resulting from heart damage).  Treatment options include  immunosuppressive medications and therapeutic monoclonal antibodies.

Paraneoplastic syndromes are rare disorders triggered by an abnormal immune response to a cancerous tumour known as a neoplasm. These disorders are most common in middle-aged to older people with lung, ovarian, lymphatic or breast cancer. Symptoms may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo or dizziness. Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.   Currently there are no cures for paraneoplastic syndromes.  However, complete surgical excision of the tumour may result in improved symptoms and treatments are available that can decrease the autoimmune response.  

What happens if I have an autoimmune disease?

There are many different autoimmune diseases with different treatments and consequences for people with these diseases. It is important to find out as much as possible about your autoimmune disease by asking questions of your treating physician.

There are also many patient support organisations and foundations that offer information and support. Some of these are listed on the ASCIA website www.allergy.org.au/patients/patient-support-organisations

You can learn about autoimmune disease from books and the internet, however you need to be aware that what is actually written may not apply to you, and you should always check the information with your treating physician.

© ASCIA 2016

ASCIA is the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand

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This document has been developed and peer reviewed by ASCIA members and is based on expert opinion and the available published literature at the time of review. Information contained in this document is not intended to replace medical advice and any questions regarding a medical diagnosis or treatment should be directed to a medical practitioner. Development of this document is not funded by any commercial sources and is not influenced by commercial organisations.

Content last updated 2016

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