Primary Immunodeficiencies

pdfASCIA Fast Facts Primary Immunodeficiencies 2019393.4 KB

  1. Primary immunodeficienciesPrimary immunodeficiencies (PIDs) are a group of more than 400 potentially serious disorders that can lead to frequent or severe infections, swellings and autoimmune problems. 
  1. PIDs can be caused by defects in the genes that control the immune system, and may be inherited. PIDs are different to AIDS (acquired immunodeficiency syndrome) that is due to human immunodeficiency virus (HIV).
  1. PID symptoms often appear in childhood, but some can first appear in adults. Research and advances in therapies have resulted in improved health and a longer life for people with PIDs. Early diagnises of PIDs is important, since delayed treatment can result in complications, which may be life threatening.
  1. PIDs can be grouped according to what part of the immune system is affected:
  • Antibody deficiencies such as common variable immunodeficiency (CVID) and X-linked agammaglobulinaemia.
  • Combined immune deficiencies such as severe combined immunodeficiency (SCID).
  • Phagocytic cell deficiencies such as chronic granulocatous disease (CGD).
  • Immune dysregulation such as IPEX, APECED, ALPS and autoinflammatory disorders.
  • Complement deficiencies such as hereditary angioedema (HAE) 
  1. Immunoglobulin replacement therapy (IRT)is one of the most effective and commonly used treatments for some PIDs. IRT can be given using intravenous immunoglobulin (IVIG) injected into the veins, or given at home using subcutaneous immunoglobulin (SCIG) that is injected under the skin. 
  1. Other treatment options for PIDs include antibiotics, immunomodulation, haematopoeitic stem cell transplants (HSCT) and HAE treatments.

More information: www.immunodeficiencies.org.au

Other Fast Facts: www.allergy.org.au/patients/fast-facts 

© ASCIA 2019

ASCIA is the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand

ASCIA Fast Facts have been developed from ASCIA information, based on published literature and expert review. www.allergy.org.au/patients/fast-facts 

Content updated March 2019

Mod ASCIA Member
Donate to AIFA
go to NAS website
Member Login
ASCIA Update

Information for the community about allergic diseases, immunodeficiencies and other immune diseases.
See latest edition here...
Join our mailing list:

About ASCIA

ASCIA is the peak professional body of clinical immunology and allergy in Australia and New Zealand
ASCIA promotes and advances the study and knowledge of allergy and other immune diseases

Quick Links

About ASCIA

ASCIA is a registered trademark of the Australasian Society of Clinical Immunology and Allergy. All content is subject to copyright for the Australasian Society of Clinical Immunology and Allergy. Read more...

The content for the website is developed and approved by ASCIA Committee and ASCIA Working Party Members. Read more...

Disclaimer I Privacy

The ASCIA website is intended for use by ASCIA members, health professionals and the general public. The content provided is for education, communication and information purposes only and is not intended to replace or constitute medical advice or treatments. Read more...

ASCIA respects your privacy. Read our privacy policy here...

Sponsors | Advertising

ASCIA does not endorse products from sponsoring organisations, nor is it influenced by sponsoring organisations with regard to the content of education programs and websites. 

The ASCIA website does not accept advertising. Any link to a third-party website does not imply any endorsement by ASCIA.

Accreditiation

healthdirect
This website is certified by Health On the Net Foundation. Click to verify.This site complies with the HONcode standard for trustworthy health information.Verify here.